Uses of chalcone acetophenone to synthesis heterocyclic compounds with cytotoxic and c-Met kinase activities
نویسندگان
چکیده
ABSTRACT. The aim of present study was the uses a series α,β-unsaturated carbonyl compounds (chalcones), in synthesis pyridine, pyran, thiophene, thiazole, together with their heterocyclic synthesis. work has resulted variety 2,5-dihydropyridine, hydrazide-hydrazone, thiophene derivatives, coumarin, pyran and thiazolo[4,5-d]thiazole derivatives. antitumor activities newly synthesized products were carried out against three cancer cell lines namely MCF-7, NCI-H460 SF-268 normal human line WI38. In addition, inhibitions most c-Met kinase studied results showed that many high inhibitions, these are considered as promising anticancer agents. obtained encouraged further future. 
 KEY WORDS: Chalcones, Heterocyclic, Pyridine, Pyran, Thiophene, Thiazole, Antitumor
 Bull. Chem. Soc. Ethiop. 2022, 36(1), 149-172. DOI: https://dx.doi.org/10.4314/bcse.v36i1.13
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ژورنال
عنوان ژورنال: Bulletin of The Chemical Society of Ethiopia
سال: 2022
ISSN: ['1011-3924', '1726-801X']
DOI: https://doi.org/10.4314/bcse.v36i1.13